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                               November 9, 2023

       Daniel Jones
       Chief Executive Officer
       SeqLL, Inc.
       3 Federal Street
       Billerica, MA 01821

                                                        Re: SeqLL, Inc.
                                                            Amendment No. 7 to
Registration Statement on Form S-1
                                                            Filed November 7,
2023
                                                            File No. 333-272908

       Dear Daniel Jones:

            We have reviewed your amended registration statement and have the
following
       comments.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe a comment applies to your
facts and circumstances
       or do not believe an amendment is appropriate, please tell us why in
your response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to this letter, we may have additional comments.
Unless we note otherwise,
       any references to prior comments are to comments in our November 6, 2023
letter.

       Amendment No. 7 to Registration Statement on Form S-1

       Risk Factors
       General Risks Affecting Our Business
       We will be required to raise additional funds prior to the maturity date
of the Merger Note to
       repay such Note and our other outstanding..., page 25

   1.                                                   We note your response
to comment one that the maturity date of the Merger Note is now
                                                        April 30, 2024. Please
update this risk factor to reflect that new maturity date.
       Capitalization, page 37

   2.                                                   Please expand note (1)
to clearly explain that the joint and several debt will not be
                                                        released until the
Merger Note is paid in full, and explain here, or provide a cross
                                                        reference to a
discussion on the company's plans for Merger Note repayment.
 Daniel Jones
SeqLL, Inc.
November 9, 2023
Page 2
Unaudited Pro Forma Condensed Combined Balance Sheets
Note 3: Adjustments to Unaudited Pro Forma Condensed Combined Balance Sheet,
page 68

3.    We note your response to prior comment four, but are unable to locate an
adjustment to
      Current Liabilities for the $20,000,000 Merger Note. Please advise.
4.    Please revise adjustment 2(d) to clearly explain the assumptions involved
in adjusting
      notes payable pursuant to Item 11-02(a)(8) of Regulation S-X.
Additionally, the note
      should clearly list the components of the adjustment, or the adjustments
should be listed
      separately in the adjustment column on the pro forma balance sheet.
5.    We note your response to prior comment three that Lyneer has only
reflected the $35
      million of debt obligations it expects to be responsible for repayment;
however, we note
      that the joint and several debt will not be released until the Merger
Note is paid in full, and
      that you believe you do not have sufficient liquidity and capital
resources to pay the
      Merger Note in full when due. Additionally, we note that Lyneer and IDC
do not expect
      to cure events of default on the existing indebtedness prior to the
November 17, 2023
      forbearance extension. It therefore appears that the historical notes
payable should not be
      adjusted, and that the total amount of Lyneer's historical notes payable
should be
      classified as current in the pro forma balance sheet. Please revise or
expand your
      disclosure to clearly explain how the consummation of transactions
supporting the current
      presentation have occurred or are probable pursuant to Item 11-01(a)(8)
of Regulation S-
      X. Please note that changes in presentation should also be made to the
pro forma as
      adjusted column in the Capitalization table on page 37.
        Please contact Ta Tanisha Meadows at 202-551-3322 or Theresa Brillant
at 202-551-
3307 if you have questions regarding comments on the financial statements and
related
matters. Please contact Nicholas Nalbantian at 202-551-7470 or Donald Field at
202-551-3680
with any other questions.



                                                             Sincerely,
FirstName LastNameDaniel Jones
                                                             Division of
Corporation Finance
Comapany NameSeqLL, Inc.
                                                             Office of Trade &
Services
November 9, 2023 Page 2
cc:       Eric M. Hellige
FirstName LastName